My degree of myopia was less than 6 diopters so I would have been classified as "low risk for haze" in the studies I have read. In addition, I read that modern PRK (eg something like SmartSurface technology) results in smoother post-ablation surfaces which further decreases risk of haze...and that even severe cases of haze from early PRK clinical trials had many of them heal and go away on their own over time.guang34 wrote: ↑Jun 1st, 2017 12:03 pmI chanced upon this thread while doing some reading on the TransPRK + SmartPulse technology on the Schwind Amaris platform as I am thinking of undergoing refractive surgery as it seems to be the best in terms of preserving the strength of the cornea and minimal intraoperative complication risk. The only drawback seems to be the longer recovery time. My only hesitation is the usage of Mitomycin-C (aka MMC) to prevent haze. I understand that the current protocol is that most surgeons would apply a 0.02% Mitomycin-C on the stromal bed for perhaps around 15 to less than a minute (depending on surgeon's preference).
While doing further reading up, it seems that MMC is a approved drug used for cancer treatment and is known to be carcinogenic. Although MMC has a long track record in eye surgery such as for treatment of glaucoma and pterygium as you can find published papers in journals dating back around 20 years with short-term side effects and no long term effects, which are well reported, I am hesitating a bit at the thought of using such a drug for an elective procedure as it seems that ophthalmologists are uncertain if there are any long term side effects on the usage of MMC in refractive surgery.
For those who have undergone the TransPRK + SmartPulse or SmartSurface procedure, what are your thoughts with regards to usage of MMC ? Was MMC used for your procedure ?
Therefore, I requested that MMC be skipped for me but Dr. Lin did not seem to like the idea. He specifically asked me what concerned me about it, and I don't like that I read it crosslinks DNA in endothelial cells and damages them permanently, a non-regenerating set of cells (as far as we know right now.) He replied that the way he applies it won't touch the endothelium. So...I backed off, not without lingering doubts but I didn't want to argue with my surgeon! Heh.
So, for < 6.00 corrections...
- the risk of haze is low
- it seems haze, if it occurs, can be only temporarily much of the time
- modern PRK techniques, technology and healing protocols (eg bandage contact lenses) seem to have reduced risk of haze further
- MMC may increase risk or degree of post surgical eye dryness
- the long term consequences and exact mechanism in eye surgeries are still unknown
- if haze does occur, it can always be treated with another lasering and MMC then applied
I didn't like the benefit vs risk comparison. But...I got it done.