Only if you have made major changes in your status. Then you are re-applying.
"Your membership in NEXUS is valid for five years. Please note that a streamlined renewal process is now in place. It is no longer necessary for the majority of renewing members who have not had changes to their information and have maintained their low-risk status to attend an interview".
https://www.cbsa-asfc.gc.ca/prog/nexus/ ... l-eng.html