Health & Wellness

US to recommend Covid19 vaccine boosters at 8 months

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Dec 20, 2018
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US to recommend Covid19 vaccine boosters at 8 months

https://apnews.com/article/health-coron ... 4c2c02ec1c

With other countries (including US) giving boosters to immunocompromised, those with certain preexisting conditions and elderly , US is set to recommend general public get vaccine boosters at 8 months. Recent Israeli data showed a 3rd shot generated 3x as much antibodies as the second shot



WASHINGTON (AP) — U.S. experts are expected to recommend COVID-19 vaccine boosters for all Americans, regardless of age, eight months after they received their second dose of the shot, to ensure lasting protection against the coronavirus as the delta variant spreads across the country.

Federal health officials have been actively looking at whether extra shots for the vaccinated would be needed as early as this fall, reviewing case numbers in the U.S. as well as the situation in other countries such as Israel, where preliminary studies suggest the vaccine’s protection against serious illness dropped among those vaccinated in January.

An announcement on the U.S. booster recommendation was expected as soon as this week, according to two people familiar with the matter who spoke to The Associated Press on the condition of anonymity to discuss internal deliberations.

Doses would only begin to be administered widely once the Food and Drug Administration formally approves the vaccines. That action is expected for the Pfizer shot in the coming weeks.
Last edited by StatsGuy on Aug 17th, 2021 1:40 am, edited 1 time in total.
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Think of the Childre…
That's when the Covid pills comes out.

WOULD SOMEBODY THINK OF THE CHILDREN!!!
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Hopefully Health Canada is listening.
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Wonder at what point will they have to come up with a booster specifically for a variant type and how difficult would it be to produce ? Seems like the strategy here is overwhelm with quantity of antibody rather than specificity of the antibody attachment?
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coilz wrote: Wonder at what point will they have to come up with a booster specifically for a variant type and how difficult would it be to produce ? Seems like the strategy here is overwhelm with quantity of antibody rather than specificity of the antibody attachment?
They are being fabricated, but approving them, manufacturing them, producing them at a massive scale and distributing them will take a lot of time.

In the interim, Western governments will give booster shots to better halt the spread of the Delta variant, since they will already have the doses on hand, and since Delta is still spreading due in large part to unvaccinated individuals.
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Poutinesauce wrote: They are being fabricated, but approving them, manufacturing them, producing them at a massive scale and distributing them will take a lot of time.
Not more time than the original vaccine. Nothing will change in the manufacturing process except for the initial sequence inserted into a plasmid. They could have done it yesterday. And they did it really fast for the original vaccine. It's a big question why they are not changing the vaccine to make it work better against Delta. Maybe they accumulated a lot of the original vaccine doses and don't want to lose money by not selling it.
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alpovs wrote: Not more time than the original vaccine. Nothing will change in the manufacturing process except for the initial sequence inserted into a plasmid. They could have done it yesterday. And they did it really fast for the original vaccine. It's a big question why they are not changing the vaccine to make it work better against Delta. Maybe they accumulated a lot of the original vaccine doses and don't want to lose money by not selling it.
It requires complex readjusments across the entire supply chain.
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StatsGuy wrote: https://apnews.com/article/health-coron ... 4c2c02ec1c

With other countries (including US) giving boosters to immunocompromised, those with certain preexisting conditions and elderly , US is set to recommend general public get vaccine boosters at 8 months. Recent Israeli data showed a 3rd shot generated 3x as much antibodies as the second shot
I really don't get where this is coming from, because the CDC just said no!

https://thehill.com/policy/healthcare/5 ... e-boosters
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Poutinesauce wrote: It requires complex readjusments across the entire supply chain.
Seriously? What supply chain? Elaborate please. They only need to change the initial plasmid. Further enzymatic reactions are the same.
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mr_raider wrote: I really don't get where this is coming from, because the CDC just said no!

https://thehill.com/policy/healthcare/5 ... e-boosters
"Official" now. Based on your link, CDC isn't calling it a booster because a valid regimen is now 3 doses? So it's not a booster ... semantics lol


https://www.nbcnews.com/health/health-n ... e-n1277059
Top U.S. health officials announced Wednesday that the country has developed a plan to start offering Covid-19 booster shots to all Americans beginning the third week of September, citing evidence that protection is waning not only against hospitalization and death, but also mild and moderate infections, as the highly contagious delta variant continues to spread.

"Based on our latest assessment, the current protection against severe disease, hospitalization, and death could diminish in the months ahead, especially among those who are at higher risk or were vaccinated during the earlier phases of the vaccination rollout," federal health officials said in a joint statement Wednesday.
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when do we need 4th dose?
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if US is at 8 mos, add another 50% for Canada = 12 months... why? just bec health canada has consulted "their experts" Face With Tears Of Joy
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golferbowl wrote: if US is at 8 mos, add another 50% for Canada = 12 months... why? just bec health canada has consulted "their experts" Face With Tears Of Joy
Well it very well maybe. The risk of breakthrough transmission is directly related to the overall vaccination in population/community spread. Canada has way higher Vaccination rates and lower community spread so I wouldn't be surprised that therefore, we don't need a booster as soon because the risk/protection from the vaccines is higher here due to lower community spread

Vaccine effectiveness is not same everywhere, it's correlated to overall Vaccination rates which ties to community spread
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StatsGuy wrote: Vaccine effectiveness is not same everywhere, it's correlated to overall Vaccination rates which ties to community spread
This is not correct. Vaccine efficacy is determined relative to a control group from the same community. Besides, the chance of getting infected depends on the levels of antibodies that are independent of community. You are confusing different risks.
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StatsGuy wrote: "Official" now. Based on your link, CDC isn't calling it a booster because a valid regimen is now 3 doses? So it's not a booster ... semantics lol


https://www.nbcnews.com/health/health-n ... e-n1277059
No, the CDC defined a third dose is for immunocompromised as part of the vaccine series for them alone. The “booster” is what the government have said everyone else can get, which is what the CDC have not recommended.
Camille Nelson Kotton, a member of the CDC’s independent vaccine advisory panel, said the public should realize there's “a pretty big distinction” between a booster dose for the general public and a third dose for people with moderate and severely compromised immune systems.
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golferbowl wrote: if US is at 8 mos, add another 50% for Canada = 12 months... why? just bec health canada has consulted "their experts" Face With Tears Of Joy
No.

the main reason Canada can wait is because of the delayed interval. Most people got their second dose after April, which means they won't be up until next year. Plus I suspect the longer interval will actual lessen any "waning" effect that is being described.

A few LTC residents and health care workers did get their two doses at 21 days back in January. Canada has a stockpile of 9 million doses which will cover all LTC resients, health care workers and pretty much every one over 75.
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alpovs wrote: This is not correct. Vaccine efficacy is determined relative to a control group from the same community. Besides, the chance of getting infected depends on the levels of antibodies that are independent of community. You are confusing different risks.
I said "effectiveness" which is not same as "efficacy"

https://www.gavi.org/vaccineswork/what- ... al%20world.
Efficacy is the degree to which a vaccine prevents disease, and possibly also transmission, under ideal and controlled circumstances – comparing a vaccinated group with a placebo group. Effectiveness meanwhile refers to how well it performs in the real world.
so the "community" here is different than other locations no?

therefore vaccine effectiveness will be different as that is significantly influenced by the local/jurisdictional context/situation
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StatsGuy wrote: I said "effectiveness" which is not same as "efficacy"

https://www.gavi.org/vaccineswork/what- ... al%20world.



so the "community" here is different than other locations no?

therefore vaccine effectiveness will be different as that is significantly influenced by the local/jurisdictional context/situation
I would really like to see the data published or released that is motivating this recommendation.

US vaccine surveillance is abysmal, I really hope they have quality data from other countries.
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mr_raider wrote: I would really like to see the data published or released that is motivating this recommendation.

US vaccine surveillance is abysmal, I really hope they have quality data from other countries.
I guess Israel is probably the most robust in terms of surveillance ... you can probably find some of their published data sourced in this article

https://www.wsj.com/articles/pfizers-co ... 1629308427

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